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Hello - I've been feeling pretty bad (severe pain) the last week. I started PT and also got a prescription for Celebrex. My doctor also gave me a muscle relaxer (tizanidine). I'm afraid to take it due to my addiction. Any Opinion?
"Drug Abuse and Dependence
Abuse potential was not evaluated in human studies. Rats were able to distinguish Tizanidine from saline in a standard discrimination paradigm, after training, but failed to generalize the effects of morphine, cocaine, diazepam, or phenobarbital to Tizanidine. Monkeys were shown to self-administer Tizanidine in a dose-dependent manner, and abrupt cessation of Tizanidine produced transient signs of withdrawal at doses > 35 times the maximum recommended human dose on a mg/m2 basis. These transient withdrawal signs (increased locomotion, body twitching, and aversive behavior toward the observer) were not reversed by naloxone administration.
Tizanidine is closely related to clonidine, which is often abused in combination with narcotics and is known to cause symptoms of rebound upon abrupt withdrawal. Three cases of rebound symptoms on sudden withdrawal of Tizanidine have been reported. These case reports suggest that these patients were also misusing narcotics. Withdrawal symptoms included hypertension, tachycardia, hypertonia, tremor, and anxiety. As with clonidine, withdrawal is expected to be more likely in cases where high doses are used, especially for prolonged periods."
Information in this forum is not monitored or provided by a medical professional. The information reflects member opinions only. Do not act on advice from these forums without first consulting a qualified medical professional. All content is copyrighted and protected by Aelius Group.