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  1. #1
    dvo
    dvo is offline Junior Member
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    Default change from Buprenx to MS Contin

    Need a doctors advice. Need to change from Buprenex to MS Contin for intractable pain. Question/advice: Can i just change to the MS Contin from 0.60mg of Buprenex 4x/day. Reason I need to change to MS Contin is need to use new drug that is used to regain bowel movements for opiate dependent patients (new drug is methylnaltrexone/Relistor.

    Relistor doesnt make me have bm's while on buprenex, so wanting to switch to MS contin which is a pure opiate vs Buprenex which a mixed opiate --- thus, Relistor doesnt work to restore BM's if using methlnaltrexone, but i know methylnaltrexone/Relistor does work to restore bm's if I am using in MS Contin.

    I assume methylnaltrexone doesnt work for Buprenex due to naltrexone/naloxne/narcan doesnt work to reverse buprenex.

    Need help Please! Advise is really needed. --- thanks in advance ... dvo

  2. #2
    KB
    KB is offline Senior Member
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    Default

    ok, you want to go on morphine just to have a bowel movement??? that is a strange predicament you're in. why were you on bupe? if it was for opiate addiction--going back on morphine isn't a real good idea! i guess you have to decide what is more important--your addiction or your bowels?? there are many laxatives that can be taken while on bupe. have you tried any? is bupe not controlling your pain?? we need more details!

    robin

  3. #3
    mmaj is offline Junior Member
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    Default Re: change from Buprenx to MS Contin

    To DVO...I would do some more research before asking your doctor to switch you from Buprenex to MS Contin. I really do understand what your delema is being that myself I am on Suboxone and suffer from severe constipation. None of the medications and remedies I have tried for opioid induced constipation have worked, with the exception of Enulose (Lactulose). Have you ever given that a try? Also, I was curious to know if the Relistor reduced the analgesic effect of Buprenex? If it did I would suggest that the combination MS Contin/Relistor might do the same. I understand Buprenex, which a mixed opiate, is different from MS Contin which is a pure opiate so to speak so in theory your assumption for wanting to switch sounds very valid. Best of luck! I would be interested to hear any patients input on this.

    In response to KB's post, "ok, you want to go on morphine just to have a bowel movement??? that is a strange predicament you're in. why were you on bupe? if it was for opiate addiction--going back on morphine isn't a real good idea! i guess you have to decide what is more important--your addiction or your bowels?? there are many laxatives that can be taken while on bupe. have you tried any? is bupe not controlling your pain?? we need more details!"

    DVO states he/she is prescribed for intractable pain. My understanding is that Buprenex is never prescribed for addiction in an outpatient setting, but Suboxone is. Two different drugs with the same active ingredient.

    Just my opinion. I don't believe all the hype from 'big pharma' companies and their claims about what is shown from their studies. I haven't seen any real positive claims from actual patients yet other. From Wikipedia: Methylnaltrexone - Wikipedia, the free encyclopedia

    Methylnaltrexone (MNTX, trade name Relistor) is one of the newer agents of peripherally-acting μ-opioid antagonists that act to reverse some of the side effects of opioid drugs such as constipation without affecting analgesia or precipitating withdrawals. Because it contains a permanently charged tetravalent nitrogen atom, it cannot cross the blood-brain barrier, and so has antagonist effects throughout the body, counteracting effects such as itching and constipation, but without affecting opioid effects in the brain such as analgesia.[1] However, since a significant fraction (up to 60 %) of opioid analgesia can be mediated by opioid receptors on peripheral sensory neurons, particularly in inflammatory conditions such as arthritis, traumatic or surgical pain, [2] MNTX may increase pain under such circumstances.

    I think this is an interesting read for anyone interested in addiction medicine and OIC (Opioid induced constipation): New discoveries after Suboxone, continued | Suboxone Talk Zone: A Suboxone Blog

  4. #4
    jdude's Avatar
    jdude is offline Senior Member
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    Default Re: change from Buprenx to MS Contin

    Welcome to ODR mmaj.
    Not sure of your quest, or how we can help. Maybe you'd want to start your own thread?
    But chances are after 2 1/2 years, dvo may have found a solution?
    You can't solve problems by using the same kind of thinking that caused them in the first place.

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